Drug combinations: Dangerous liaisons or great expectations?

Dangerous liaisons

Cells during mitosis and meiosis undergo chromosome condensation through a process that depends on evolutionary conserved large protein complexes known as condensins. There are two condensing complexes, condensin i and ii, each of which is composed of five subunits. Condensin i and ii play essential, yet distinct, roles in chromosome condensation and segregation during mitosis. Recent findings ...

Smoking and asthma: dangerous liaisons.

Cigarette smoking and asthma interact to induce important adverse effects on clinical, prognostic and therapeutic outcomes. This review examines recent evidence on the harmful effects of smoking in asthma, possible underlying inflammatory mechanisms for this altered response, management options for these patients and potential future therapeutic directions. Active smokers, particularly females,...

Ferritin and metallothionein: dangerous liaisons.

Ferritin (Ft) interaction with the Zn-complexes of mammalian MT1, MT2 and MT3 metallothioneins (MT) leads to simultaneous Fe(II) and Zn(II) release.

Dangerous and Deadly Drug Combinations Drug Interaction Checker

Drug/drug interactions are considered preventable errors. With the advent of electronic prescribing, the hope was that software would warn prescribers about interactions between one or more drugs that the patient is taking, and these alerts are common. They are so ubiquitous, in fact, that alerts are often overridden in the prescribing process. Clinicians cannot rely on prescribing software to ...

Dangerous liaisons? Industry relations with health professionals.